Understanding the Two-Stage Effects of Medical Cannabis

Understanding the Two-Stage Effects of Medical Cannabis

Have you ever observed that although ingesting a single dose of an edible might make you feel relaxed and content, consuming three times the recommended amount can lead to paranoia and anxiety? If this describes your experience with medical cannabis, it’s because its effects are two-phased.

When using medicinal cannabis, differing doses of cannabinoids like CBD and THC provide contrasting mental and bodily experiences. A person may feel more alert after ingesting a high amount of one cannabinoid, yet more relaxed after ingesting a moderate quantity of the same molecule (or vice-versa).

Find out how to get the most out of your medicinal cannabis experience by learning more about the science underlying its biphasic effects and determining the optimal dosage.

The Meaning of the “Biphasic Effect”

Biphasic Effect

The term “biphasic effect” describes the phenomenon wherein a drug’s low and high dosages have contradictory effects. Some people find that very low dosages of THC might help them relax. However, those same folks could experience paranoia and even hallucinations if they consume large amounts of THC.

Drugs other than medical cannabis also have biphasic effects, with opposing responses at high and low dosages. For instance, whereas a moderate amount of alcohol might give you a nice “high,” excessive use of this depressant can lead to feelings of sadness.

The hippocampus in particular is at the origin of all biphasic effects. Medicinal cannabis and other medications interact with dopamine receptors, serotonin receptors, and other critical neurotransmitters in the brain in different ways depending on the dosage.

A Look at Medical Cannabis’ Two-Phase Effects

THC’s complex effects warrant more caution than those of CBD or other lesser cannabinoids. That’s because THC has such a profound effect on people’s mental and bodily states. Here are some instances of THC’s possible dual effects, supported by research:

For example, modest dosages have a beneficial effect on memory and cognition, whereas excessive levels have the opposite effect.

When it comes to anxiety, smaller dosages alleviate symptoms while excessive levels amplify them.

Increased fertility at lower dosages, decreased fertility at higher doses

The biphasic effects of THC have been studied extensively, however, most of these investigations have been conducted on animals. The potential for THC to have biphasic effects in humans necessitates further human-based studies and studies.

Even while CBD’s biphasic nature is less pronounced than that of THC, the psychoactive component of the cannabis plant, it is still present. Generally speaking, CBD is more stimulating at lower dosages and more tranquil at larger ones. In certain cases, the cyclical effects of THC and CBD may be more noticeable in those who have been diagnosed with anxiety or panic disorder.

Tetrahydrocannabivarin is another cannabinoid that has two phases of action (THCV). In small quantities, THCV can counteract the psychoactivity of THC, while in larger amounts, it can boost the psychoactivity of medicinal cannabis through a process known as synergy.

Finding the Appropriate Dose

The difference between a good experience and a terrible one is all in the dosage when using medical cannabis. Although it is impossible to predict how you will react to marijuana (particularly if you are unfamiliar with the plant), there are steps you can take to mitigate any negative outcomes.

Here are some guidelines to help you mix together the perfect “medicinal cannabis cocktail”:


It’s best to ease into things

Although your medical cannabis dosage can be increased at any time, it cannot be decreased. If you have never used the psychoactive cannabinoid THC before, it’s best to start with the least dose possible.

Consult a medical professional who is familiar with marijuana if you want to use it to treat a specific medical problem. Chronic Therapy can help you find a qualified medical marijuana doctor in your area if you don’t already have one.

Since too much of the cannabinoid THC can cause anxiousness, paranoia, and fear, it is commonly to blame for a bad time when using medical cannabis.

To lessen the likelihood of unpleasant psychoactive effects, try starting with 5 milligrams of THC or less. To get the most out of your pot, smoke it gently over a period of a few hours rather than all in one sitting. You may get your desired high after an hour of gradual, low-dose ingestion.

You Must Select the Appropriate Ingestion Technique

There may be a difference in effectiveness between various methods of ingesting medical cannabis. The effects of edibles are widely believed to be the most potent and long-lasting. Many people have ended up in the hospital after consuming excessive amounts of marijuana treats.

For therapeutic purposes, cannabis oil can be used topically or taken orally in the form of a tincture rather than baked goods like pot brownies (sublingual). If you do decide to ingest medical cannabis, it’s best to take things gently and steadily, starting with a lower dose of CBD to THC.

Incorporate CBD Products into Your Routine

The therapeutic advantages of medical cannabis can be experienced with very little THC intake. CBD products may be found in many different types of establishments.

Products labeled as CBD cannot include more than 0.3% THC. If you don’t have access to medicinal marijuana in your state, CBD products are a viable alternative.

To conclude

Medicinal marijuana has two distinct but manageable phases; both can be mitigated with the correct dosage and CBD: THC ratio. Finding the right dosage and administration technique for you may need some experimentation.

In general, THC can assist relieve anxiety and sadness at low dosages but at higher amounts, it can cause anxiety or despair.

However, CBD may have calming effects at moderate to high dosages, reducing anxiety, while CBD at lower doses may have more stimulating effects, thus making it less effective at managing anxiety or depression.



We know you might be curious to find out more information and discuss medicinal cannabis uses, or where to get legal medicinal cannabis products in Australia, who is authorised to prescribe medicinal cannabis products to you, and we know lots of people are also worried about the use of medicinal cannabis.

For all these inquiries; including most medicinal cannabis products available on the market, prescribing medicinal cannabis, information about smoking cannabis, how to bring medicinal cannabis product on travel, medical conditions that can be cured by medical cannabis products, recreational cannabis, other general use of cannabis, you should schedule a consultation session today with our experts at Chronic Therapy to get medical professionals advice about any of the above mentions.